mips1 mutants display pleiotropic defects, including reduced root growth, abnormal vein formation in cotyledons ( 2, 3 ) and defects in auxin polar transport due to alterations in lipid metabolism ( 4 ). The Arabidopsis genome encompasses three isoforms of MIPS, but MIPS1 seems the main player in MI biosynthesis because mips1 mutants have drastically reduced MI content. Loss-of-function studies highlighted the diversity of crucial cellular processes relying on MI. The rate-limiting step for MI biosynthesis is catalyzed by the MI phosphate synthase (MIPS, E.C.5.5.1.4), and its function has been investigated in various plant species. In plants, products of MI metabolism are involved in diverse processes such as signal transduction, second messenger signaling, stress response, cell wall biogenesis and chromatin remodeling ( 1 ). MI is required for the biosynthesis of a huge variety of cellular components, and thereby plays a crucial role in growth and development. Thus, in plants, MIPS1 appears to have evolved as a protein that connects cellular metabolism, pathogen response and chromatin remodeling.Īlthough it was first isolated from muscles, myo-inositol (MI) is a ubiquitous compound present in all living organisms. Furthermore, on activation of pathogen response, MIPS1 expression is reduced epigenetically, providing evidence for a complex regulatory mechanism acting at the transcriptional level. Here, we demonstrate that MIPS1 binds directly to its promoter to stimulate its own expression by locally inhibiting the spreading of ATXR5/6-dependent heterochromatin marks coming from a transposable element. Surprisingly, we found this enzyme to be imported in the nucleus and to interact with the histone methyltransferases ATXR5 and ATXR6, raising the question of whether MIPS1 has a function in transcriptional regulation. Lock with key for lowered and/or raised position.Because regulation of its activity is instrumental either to support cell proliferation and growth or to promote cell death, the universal myo-inositol phosphate synthase (MIPS), responsible for myo-inositol biosynthesis, is a critical enzyme of primary metabolism. All connectors and feet are made of stainless steel. There are also several connectors for corner and wall attachment. There are several types of feet for installation. Available as an option is powder coated in white, black or any standard RAL colour. Frosted or patterned foil, grey glass or other materials is available as an option. With SPLITT you get a complete glazing with maximum opening area thanks to the two movable panes that open both upwards and downwards.ĥ mm laminated glass in the moving parts and 6 mm laminated glass in the fixed parts in standard performance. SPLITT is a version of height adjustable glazing for environments where you can attach the glazing upwards against a ceiling, balcony, pergola etc. Attachment is made on the sides and/or upwards to, for example, ceiling or pergola.
Standard overhead fixed glass is delivered with extended posts to be attached on the existing glazing but it is also available without side posts. Note that the maximum width might be affected based on the conditions of wind load in the area and the installation height. Refers to fixed railings and standard height adjustable screens. We guarantee you a safe railing or height-adjustable glazing solution of the highest quality. Open terrace or glassed-in restaurant? With Café au Lä® you can have both. Café au Lä® is also CE marked according to EN 1090 and thereby approved for installation on balconies and terraces where there is a risk of falls and injuries. As a fixed railing, as height adjustable windscreen, with fixed overhead glass or as SPLITT for a complete glassed-in terrasse or balcony.Ĭafé au Lä® is tested for wind load and personal safety including heavy impacts by the SP – Technical Research Institute of Sweden. Made from aluminum, the standard design is equipped with laminated safety glass, both in the lower fixed part and in the height-adjustable part.Ĭafé au Lä® is available in several variants that all can be combined in the same installation. Guests can decide the height they want of the windscreen, whether they want to have an intimate atmosphere or want to be a part of what is going on outside.
Protection and comfort for your restaurant guestsĬafé au Lä® is the easily adjustable windscreen for restaurant terraces.
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